Fibroblasts become fat to reduce scarring

Ways to reduce saturated fat intake.

Current dietary guidelines emphasize a reduced intake of total fat. This means that (saturated) fatty acids should be replaced by carbohydrates. But are carbohydrates the optimal replacement? High-carbohydrate diets do indeed lower plasma LDL-cholesterol levels. However, both sugars and complex carbohydrates lower HDL-cholesterol and increase fasting triacylglycerol levels (Mensink & Katan, 198...

Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts

BACKGROUND To limit epidural fibrosis and prevent scar formation/nerve tethering that may contribute to chronic postoperative pain; some surgeons have utilized epidural autologous fat grafts following lumbar microdiscectomy. METHODS We investigated the correlation between post-microdiscectomy epidural scarring [including select magnetic resonance imaging (MRI) studies] and clinical outcomes i...

Anti-scarring effects of butaprost on human subconjunctival Tenon's fibroblasts.

AIM To investigate the toxicity of the E-prostanoid 2 (EP2) receptor agonist, butaprost against human subconjunctival (Tenon's capsule) fibroblasts, and to determine the underlying mechanism. METHODS We isolated Tenon's fibroblasts from the subconjunctival area of healthy subjects and evaluated the types of EP receptors expressed using quantitative real-time reverse transcription polymerase c...

Wound care: Patch could improve healing and reduce scarring

How to become a professor in epidemiology?

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